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KMID : 0351819930340020107
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Kyunpook University Medical Journal
1993 Volume.34 No. 2 p.107 ~ p.116
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Convulsion and Neurodegeneration by Kainin Acid are Related to N-Methyl-D-Aspartate Receptor
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Abstract
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We intended to examine the effects of a non-competitive N-methyl-D-aspartate(NMDA) receptor antagonist, MK-801, on the kainic acid(KA)-induced seizures in rats. The animals were divided into two groups.One was treated with KA(10mg/kg. I. p.) the
other
was with MK801 (1mg/kg. I. p.) and KA(10mg/kg. I. p.). The electrical activity at frontal and hippocampal area and behavior activity were recorded in freely moving rats. Frontal and hippocampal tissue were examined under light microscope.
The number of line crossed in open field (movement) and the number of wet dog shake (behavioral seizure) were increased in the KA-treated group. MK-801 pretreament decreased the movment and induced abnormal behavior such as head weaving, body
rolling
and ataxia. And MK-801 significantly blocked the inovement and the behavioral seizure induced by KA. The electrical activity, which consist of the amplitude, the fast frequency component and the spikes, was increased by KA treatment. This
increase
was
not blocked by MK-801 pretreatment. The neurodegeneration at frontal and hippocampal area was observed in the KA-treated rats which was protected by MK-801 pretreatment.
These results indicate that the KA-induced behavioral seizure and neurodegeneration may be
related to the NMDA subtype of glutamate receptor.
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KEYWORD
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